Dr. Cécile Lorrain

Dr.  Cécile Lorrain

Dr. Cécile Lorrain

Lecturer at the Department of Environmental Systems Science

ETH Zürich

Professur für Phytopathologie

LFW C 15

Universitätstrasse 2

8092 Zürich

Switzerland

Additional information

Research area

Research Interests

 

 

My general research interest is to study the evolutionary ecology of plant pathogenic fungi using multidisciplinary approaches. I am particularly curious to unravel how antagonistic interactions shape rapid evolution of plant-pathogens and how species maintain their evolutionary potential in human-managed environments. I employ a combination of genomics, phenomics and experimental evolution approaches to better understand the molecular basis of adaptation in plant pathogens. I am working mainly with the fungal wheat pathogen Zymoseptoria tritici causing the Septoria tritici blotch disease that damages wheat crops worldwide. Z. tritici populations harbor all of the characteristics that facilitate rapid adaptation, including large effective population sizes, short generation times, high mutation rates and extensive gene flow among populations. I am studying how Z. tritici populations respond to fluctuating environmental conditions including deployment of resistant host cultivars and the application of fungicides across different spatial and temporal scales.

Short CV

Current position: Post-doctoral fellow in the Plant Pathology Group (Pr. Bruce McDonald)

 

2019: Post-doctoral fellow in the Environmental Genomics department (Pr. Eva Stukenbrock) Max Planck Institute for Evolutionary biology & Tree/Microbe Interactions Department (UMR 1136 IAM), Ecogenomics team, INRA/Lorraine University, INRA Centre Grand Est-Nancy

 

2018: PhD in plant and forest biology, Young Scientist contract INRA, Tree/Microbe Interactions Department (UMR 1136 IAM), Ecogenomics team, INRA/Lorraine University, INRA Centre Grand Est-Nancy (France)

 

2014: Master of Science - Biotechnology, Microbiology, Nutrition and Environment, Lorraine University, Nancy (France)

 

Publications

Lorrain C, Feurtey A, Möller M, Haueisen J, Stukenbrock EH. (2021) Dynamics of transposable elements in recently diverged fungal pathogens: lineage-specific transposable element content and efficiency of genome defences. G3. 16:jkab068. doi: 10.1093/g3journal/jkab068

Möller M, Habig M, Lorrain C, Feurtey A, Haueisen J, et al. (2021) Recent loss of the Dim2 DNA methyltransferase decreases mutation rate in repeats and changes evolutionary trajectory in a fungal pathogen. PLOS Genetics 17(3): e1009448. doi:10.1371/journal.pgen.1009448

Haueisen J, Lorrain C, Stukenbrock EH. (2020) Molecular interactions of microbes and the plant phyllosphere. Cell. Dialogues Holobiont 267–285.

Feurtey A, Lorrain C, Croll D, Eschenbrenner C, Freitag M, Habig M, Haueisen J, Möller M, Schotanus K, Stukenbrock EH. (2020) Genome compartmentalization predates species divergence in the plant pathogen genus Zymoseptoria. BMC Genomics. 21(1):588. doi: 10.1186/s12864-020-06871-w.

Petre B, Lorrain C, Stukenbrock EH, Duplessis S. (2020) Host-specialized transcriptome of plant-associated organisms. Curr Opin Plant Biol. 56:81-88. doi: 10.1016/j.pbi.2020.04.007.

Lorrain C, Gonçalves Dos Santos KC, Germain H, Hecker A, Duplessis S. (2019) Advances in understanding obligate biotrophy in rust fungi. New Phytol. 222(3):1190-1206. doi: 10.1111/nph.15641. 

de Guillen K, Lorrain C, Tsan P, Barthe P, Petre B, Saveleva N, Rouhier N, Duplessis S, Padilla A, Hecker A. (2019) Structural genomics applied to the rust fungus Melampsora larici-populina reveals two candidate effector proteins adopting cystine knot and NTF2-like protein folds. Sci Rep. 2;9(1):18084. doi: 10.1038/s41598-019-53816-9.

Lorrain C, Petre B, Duplessis S (2018) Show me the way: rust effector targets in heterologous systems, Curr Opin Microbiol. 46:19-25.

Lorrain C, Marchal C, Hacquard S, Delaruelle C, Pétrowski J, Petre B, Hecker A, Frey P, Duplessis S. (2018) The Rust Fungus Melampsora larici-populina Expresses a Conserved Genetic Program and Distinct Sets of Secreted Protein Genes During Infection of Its Two Host Plants, Larch and Poplar. Mol Plant Microbe Interact. 31(7):695-706. doi: 10.1094/MPMI-12-17-0319-R.

Petre B, Lorrain C, Saunders DGO, Win J, Sklenar J, Duplessis S, Kamoun S (2016) Rust fungal effectors mimic host transit peptides to translocate into chloroplasts. Cellular Microbiology 18: 453-465.

Petre B, Saunders DGO, Sklenar J, Lorrain C, Krasileva KV, Win J, Duplessis S, Kamoun S (2016) Heterologous expression screens in Nicotiana benthamiana identify a candidate effector of the wheat yellow rust pathogen that associates with processing bodies. PloS One 11: e0149035.

Lorrain C, Hecker A, Duplessis S (2015) Effector-mining in the poplar rust fungus Melampsora larici-populina secretome. Mini-review, Frontiers in Plant Science 6: 1051. doi:10.3389/fpls.2015.01051.

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